Veterinary Consultation Required

This formula is for specific health conditions. Consult your veterinarian before use.

by Hill’s
Adult
Prescription Diets
Gastrointestinal Support
Indoor

Hill’s

Prescription Diet - Gastrointestinal Biome Stress Cat Food

Adult
Prescription Diets

Veterinary Consultation Required

This formula is for specific health conditions. Consult your veterinarian before use.

Gastrointestinal Support
Indoor
1

First Ingredient

Animal Protein

Flavor

Chicken

Kibble Size

~9 mm

Approximate diameter or width of each kibble
Cat Food Central Quality Score: 41 out of 100
160 views

Summary

Hill’s Prescription Diet Gastrointestinal Biome is a high-fiber dry cat food clinically shown to promote regular healthy stool in as little as 24 hours and help reduce the risk of recurrence of digestive upsets.
The first ingredient is Meat and Animal Derivatives (chicken 14%), providing the lead animal protein source, complemented by chicken and turkey meal for additional amino acids.
At 36% crude protein and 16.9% fat with a metabolizable energy of 3,786 kcal/kg, it offers a concentrated calorie profile that can sustain adult cats but calls for portion control in less active individuals.
Hill’s ActivBiome+ ingredient technology uses a targeted prebiotic blend to nourish the gut microbiome and stimulate beneficial postbiotics that normalize stool consistency.
Functional fibers such as dried beet pulp, ground pecan shell, and citrus pulp help regulate intestinal transit, improve fecal quality, and support a stable gut environment.
Flaxseed and fish oil supply omega-3s, including EPA (0.205%) and DHA (0.138%), which support gut mucosal integrity and a healthy inflammatory response.
Taurine at 0.21% supports heart and eye health, while antioxidants including vitamin E (706 IU/kg), vitamin C (117 mg/kg), and beta-carotene help protect tissues during periods of GI stress.
The mineral and electrolyte profile—calcium 0.79%, phosphorus 0.62%, magnesium 0.071%, potassium 0.87%, and sodium 0.29%—supports overall fluid and neuromuscular balance during digestive disturbances.
Carbohydrates from cereals, maize, and rice (NFE 30.7%) provide digestible energy, while fruit and seed ingredients contribute fermentable substrates and phytonutrients associated with gut health.
Formulated as a complete and highly digestible diet for adult cats, it is indicated for reducing intestinal absorptive disorders and compensating for maldigestion.

Pros
Expand All
1

Clinically demonstrated stool support

Shown to promote regular, healthy stool in as little as 24 hours, helping limit recurrence of digestive upsets.
2

Prebiotic and postbiotic approach

ActivBiome+ technology and a specialized fiber blend nourish beneficial bacteria and encourage helpful postbiotics for GI regularity.
3

Defined omega-3s including EPA/DHA

Fish oil and flaxseed deliver EPA (0.205%) and DHA (0.138%) to support gut lining and a balanced inflammatory response.
4

Robust antioxidant support

Vitamin E (706 IU/kg), vitamin C (117 mg/kg), and beta-carotene help protect cells during periods of gastrointestinal stress.
5

Electrolyte and mineral balance

Potassium (0.87%) and sodium (0.29%) alongside controlled calcium, phosphorus, and magnesium support normal muscle and nerve function during GI recovery.
6

Adequate protein for recovery

36% crude protein from animal sources complemented by plant proteins helps maintain lean body mass while fiber supports stool quality.
Cons
Expand All
1

Broadly defined animal sourcing

“Meat and Animal Derivatives (chicken 14%)” and unspecified “oils and fats” provide limited transparency about exact ingredients and cuts.
2

Plant protein concentrates present

Maize protein meal, rice protein, and vegetable protein extracts mean a portion of total protein is plant-derived, which some owners may wish to limit.
3

Contains grains

Cereals, maize, and rice supply carbohydrates (NFE 30.7%), which may not suit preferences for grain-free or lower-carbohydrate diets.
4

Includes milk derivatives

The presence of milk and milk derivatives may be unsuitable for cats with known dairy sensitivities.
5

Energy-dense formula

16.9% fat and 3,786 kcal/kg call for careful portion control in less active or weight-prone cats.
6

Sodium present

Contains sodium at 0.29%, so veterinary guidance is advisable for cats requiring sodium restriction.

Nutrition

Ingredients

  • Meat And Animal Derivatives (Chicken 14%)
  • Cereals
  • Vegetable Protein Extracts
  • Derivatives Of Vegetable Origin
  • Oils And Fats
  • Fruit
  • Minerals
  • Seeds
  • Milk And Milk Derivatives
  • Chicken And Turkey Meal
  • and also:
Maize Protein Meal, Animal Fat, Broken Rice, Maize, Rice Protein, Fish Oil, Vegetable Oil, Ground Pecan Shell, Dried Beet Pulp, Flaxseed, Dried Citrus Pulp, Dried Cranberries

Vitamins and Additives

  • Vitamin A 8948 IU
  • Vitamin B1 24 mg/kg
  • Vitamin B2 12 mg/kg
  • Vitamin B3 144 mg/kg
  • Vitamin B5 34.8 mg/kg
  • Vitamin B6 9.9 mg/kg
  • Vitamin B12 0.16 mg/kg
  • Vitamin C 117 mg/kg
  • Vitamin D 734 IU
  • Vitamin D3 734 IU
  • Vitamin E 706 mg/kg
  • and also:
Folic Acid (Vitamin B9) 4.51 mg/kg, Biotin (Vitamin B7) 0.44 mg/kg

Guaranteed Analysis

Crude Protein
36%
Crude Fat
16.9%
Crude Fiber
5.3%
Moisture
6%
Crude Ash
5.6%
Calcium
0.79%
Phosphorus
0.62%
Potassium
0.87%
Magnesium
0.071%
Omega 3
0.96%
Omega 6
2.96%
Metabolizable Energy
3786 kcal/kg
Carbohydrate (NFE) 30.7 %, Sodium 0.29 %, Taurine 0.21 %, DHA 0.138 %, EPA 0.205 %, Beta-Carotene 2.25 ppm

Guaranteed Analysis

Crude Protein
36%
Crude Fat
16.9%
Crude Fiber
5.3%
Moisture
6%
Crude Ash
5.6%
Calcium
0.79%
Phosphorus
0.62%
Potassium
0.87%
Magnesium
0.071%
Omega 3
0.96%
Omega 6
2.96%
Metabolizable Energy
3786 kcal/kg
Carbohydrate (NFE) 30.7 %, Sodium 0.29 %, Taurine 0.21 %, DHA 0.138 %, EPA 0.205 %, Beta-Carotene 2.25 ppm
Last reviewed:
We periodically review this product’s details and update them to match the manufacturer’s latest published information, but some changes may not be reflected immediately. View the product change history.

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Product changes
Hill’s

Prescription Diet - Gastrointestinal Biome Stress Cat Food

Product changes

17-04-2026
  • Ingredients list changed
  • Score changed from 53 -> 41
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How the score is calculated?

The actual calculation of the score is based on sophisticated and advanced algorithm that takes into account multiple parameters.

To simplify the explanation, the calculation is based on three main criteria:

(1) Amount of protein (more is better)

(2) Amount of carbohydrates (less is better)

(3) Quality and source of ingredients.

Based on that 3 main criteria, 9 score calculation rules are used to compare the different foods.

One major assumption is that the closer an ingredient is to the top of the ingredient list, the greater its relative weight and contribution to the food.

In general, cat food is composed of protein, fats, carbohydrates, fibers, vitamins, and minerals.

Protein is the most important component in a cat's diet, and cats primarily get their protein from animal meat.

Fat is a primary source of energy and essential fatty acids.

Carbohydrates are controversial in a cat's diet, as cats are obligate carnivores and typically consume very few carbohydrates.

Fibers play an important role in digestion and food absorption, and vitamins and minerals are essential for different organism functions.

Dry matter values are used to compare the amount of nutrients in different cat foods. This means that moisture is excluded from the equation to provide a more accurate comparison.

Putting all of these and more into a formula results in a product score.

The maximum score a cat food can receive is 100. Points are added or removed based on the score calculation rules.

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